Trem2/Tyrobp Signaling Protects Against Aortic Dissection and Rupture by Inhibiting Macrophage Activation in Mice
Our findings suggest a novel role for the Trem2/Tyrobp axis in AD development in mice. Enhancement of Trem2/Tyrobp signaling may represent a promising strategy for the prevention and treatment of AD. Future studies to clarify the role of Trem2/Tyrobp in human AD are warranted.
Authors
- Tingfeng Chen
- Sixu Chen (ORCID: https://orcid.org/0000-0003-2870-909X)
- Lei Lv (ORCID: https://orcid.org/0000-0003-0675-659X)
- Lei‐Bo Xu (ORCID: https://orcid.org/0000-0002-9236-5343)
- Yuna Huang (ORCID: https://orcid.org/0000-0002-7147-5834)
- Xiao Liu (ORCID: https://orcid.org/0000-0002-5570-289X)
- Maoxiong Wu (ORCID: https://orcid.org/0000-0002-6943-2763)
- Zhiteng Chen (ORCID: https://orcid.org/0000-0002-7891-5783)
- Zhaoyu Liu
- Ping Hua
- Yangxin Chen (ORCID: https://orcid.org/0000-0003-2051-9320)
- Lei Yao (ORCID: https://orcid.org/0009-0004-4930-0212)
- Zhaoqi Huang (ORCID: https://orcid.org/0000-0001-8954-2364)
- Woliang Yuan (ORCID: https://orcid.org/0009-0009-4998-0816)
- Chunling Huang (ORCID: https://orcid.org/0000-0002-5819-7307)
- Weibin Zhou
- Zenghui Zhang (ORCID: https://orcid.org/0009-0003-6245-6847)
- Jingfeng Wang
- Chi-Yu Liu
- Jiaqi He (ORCID: https://orcid.org/0000-0003-3985-5738)
Institutions
- Sun Yat-sen University (CN)
- Kunming Medical University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1161/atvbaha.124.321429
- Citations
- 12
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 5.03