Association of Genomic Alterations with the Presence of Serum Monoclonal Proteins in Chronic Lymphocytic Leukemia
The presence of a monoclonal protein detected by serum immunofixation electrophoresis (sIFE) has been reported as an adverse prognostic factor in chronic lymphocytic leukemia (CLL). However, the genetic underpinning of this finding has not been studied. We retrospectively studied 97 CLL patients with simultaneous information on sIFE and genetic alterations detected by next-generation sequencing. sIFE was positive in 49 patients. The most common isotypes were IgG κ (27%) and bi/triclonal (25%). A +sIFE was associated with a higher number of mutated genes [median 2 (range 0-3) vs. 0 (range 0-2), <i>p</i> = 0.006], and a higher frequency of unmutated IGHV status (60 vs. 29%, <i>p</i> = 0.004). An IgM monoclonal protein was associated with <i>TP53</i> mutations (36% in IgM +sIFE vs. 12% in non-IgM +sIFE or -sIFE, <i>p</i> = 0.04), and bi/triclonal proteins with <i>NOTCH1</i> mutations (33% in bi/triclonal vs. 9% in monoclonal +sIFE or -sIFE, <i>p</i> = 0.04). These data suggest an association between a +sIFE and a higher mutational burden, and some monoclonal isotypes with specific mutations.
Authors
- Nil Albiol (ORCID: https://orcid.org/0000-0003-2942-1362)
- Mònica López‐Guerra (ORCID: https://orcid.org/0000-0002-5545-0178)
- Julio Delgado (ORCID: https://orcid.org/0000-0002-5157-4376)
- Neus Villamor (ORCID: https://orcid.org/0000-0001-6538-4111)
- Elı́as Campo (ORCID: https://orcid.org/0000-0001-9850-9793)
- Juan Gonzalo Correa (ORCID: https://orcid.org/0000-0001-6470-8102)
- Marta Aymerich (ORCID: https://orcid.org/0000-0001-9750-1538)
- Ferran Nadeu (ORCID: https://orcid.org/0000-0003-2910-9440)
- Irene López‐Oreja (ORCID: https://orcid.org/0000-0001-6756-1820)
- Pablo Mozas (ORCID: https://orcid.org/0000-0001-9528-4971)
- Juan A. Piñeyroa (ORCID: https://orcid.org/0000-0003-4576-0540)
- Juan I. Aróstegui (ORCID: https://orcid.org/0000-0003-4757-504X)
- Dolors Costa (ORCID: https://orcid.org/0000-0002-8276-3292)
- Aleix Borja Fabregat Bolufer (ORCID: https://orcid.org/0000-0002-4855-0306)
- Sı́lvia Beà (ORCID: https://orcid.org/0000-0001-7192-2385)
- Dolors Colomer (ORCID: https://orcid.org/0000-0001-7486-8484)
- Ares Martínez-Farran
- Ines Monge-Escatín
Institutions
- Departament de Salut (ES)
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Cells
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3390/cells13221839
- Citations
- 2
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- Centres de Recerca de Catalunya
- Generalitat de Catalunya
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- European Regional Development Fund