Clinical Case of Acute Analgesic Nephropathy in a 14-Year-Old Child

Medications are responsible for more than a quarter of cases of acute kidney failure (AKF) in both outpatient and hospital practice. This is often due to underestimating the safety of prescribed drugs, the over-the-counter availability of medications, insufficient justification for prescriptions, and uncontrolled use. In 70–90 % of cases, acute drug-induced kidney damage presents as acute tubulointerstitial nephritis (ATIN), with a mortality rate of around 10 %. This article presents a case of acute kidney injury in a teenage girl following the use of sodium metamizole during the postoperative period. The timely application of two hemodialysis sessions helped avoid disaster, and subsequent monitoring of the patient (enalapril 2.5 mg twice daily, levocarnitine 20 % 1 teaspoon twice daily, dietary restrictions) over nearly two years showed slow recovery of kidney function, which indicates the severe nature of the kidney damage.

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Published
2024-11-06
DOI
https://doi.org/10.33667/2078-5631-2023-23-62-66
Primary Topic
Poisoning and overdose treatments
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article
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article

Clinical Case of Acute Analgesic Nephropathy in a 14-Year-Old Child

М. Н. Костылева, E. K. Petrosyan, С. С. Постников, Н. В. Теплова et al.
Medical alphabet
Poisoning and overdose treatments
article

Clinical Case of Acute Analgesic Nephropathy in a 14-Year-Old Child

М. Н. Костылева, E. K. Petrosyan, С. С. Постников, Н. В. Теплова, D. Yu. Dalakyan, J. D. Tramova, A. N. Grazzianskaya, L. B. Belousova
article en

Abstract

Medications are responsible for more than a quarter of cases of acute kidney failure (AKF) in both outpatient and hospital practice. This is often due to underestimating the safety of prescribed drugs, the over-the-counter availability of medications, insufficient justification for prescriptions, and uncontrolled use. In 70–90 % of cases, acute drug-induced kidney damage presents as acute tubulointerstitial nephritis (ATIN), with a mortality rate of around 10 %. This article presents a case of acute kidney injury in a teenage girl following the use of sodium metamizole during the postoperative period. The timely application of two hemodialysis sessions helped avoid disaster, and subsequent monitoring of the patient (enalapril 2.5 mg twice daily, levocarnitine 20 % 1 teaspoon twice daily, dietary restrictions) over nearly two years showed slow recovery of kidney function, which indicates the severe nature of the kidney damage.

Medical alphabet(23)
Pirogov Russian National Research Medical University (RU), Russian Children's Clinical Hospital (RU)
Good health and well-being
Openalex Percentile: Top 65%
Poisoning and overdose treatments
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