Clinical features of anti-SAE1 antibody-positive myositis and interstitial lung disease: a multicenter, retrospective study in Taiwan
The study suggests that strong positive SAE1 autoantibodies detected via LIA are more closely associated with IIM compared to weak positive results. A high prevalence of ILD was observed among strong positive Taiwanese patients, indicating the need for prompt screening. Patients with weak positive or discordant ANA IIF results may represent false positives with a lower ILD risk.
Authors
- Chao-Yang Hsiao
- Li Su (ORCID: https://orcid.org/0000-0002-8342-9800)
- Tien‐Ming Chan (ORCID: https://orcid.org/0000-0002-0753-4529)
- Shu-Chi Tseng (ORCID: https://orcid.org/0000-0002-9671-9006)
- Li-Chung Chiu
- Chung-Yuan Hsu
Institutions
- Chang Gung University (TW)
- National Central University (TW)
- Chang Gung Memorial Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3389/fimmu.2024.1482000
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- Chang Gung Medical Foundation
- Chang Gung Memorial Hospital, Linkou
- Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital
- Center for Big Data Analytics, University of Texas at Austin