Genetic and transcriptomic analyses of early-onset colon cancer (EOCC): a post hoc analysis of 2973 patients from two adjuvant randomized trials
In conclusion, EOCCs are diagnosed in more advanced stages, are more often dMMR, harbor a specific genetic profile, and have similar RFS when compared to LOCC, even if the age effect on RFS appeared to vary among CMS groups.
Authors
- Benoist Chibaudel (ORCID: https://orcid.org/0000-0003-1279-2044)
- Claire Mulot
- Annalice Gandini (ORCID: https://orcid.org/0000-0003-2873-5108)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- C. Gallois
- Côme Lepage (ORCID: https://orcid.org/0000-0001-9211-4707)
- Aurélien de Reyniès (ORCID: https://orcid.org/0000-0002-1328-5290)
- Natacha Agueeff
- Hélène Blons (ORCID: https://orcid.org/0000-0002-0572-8426)
- Laurent Mineur (ORCID: https://orcid.org/0000-0003-4615-4358)
- Jérôme Desrame
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- Pierre Laurent‐Puig (ORCID: https://orcid.org/0000-0001-8475-5459)
- Rosine Guimbaud (ORCID: https://orcid.org/0000-0002-8344-1762)
Institutions
- Inserm (FR)
- Université de Bourgogne (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Saint-Antoine (FR)
- Hôpital Européen (FR)
- Xinqiao Hospital (CN)
- Hôpital Privé Jean Mermo (FR)
- Centre de Recherche Saint-Antoine (FR)
- Institut Hospitalier Franco Britannique (FR)
- Ospedale Policlinico San Martino (IT)
- Institut Sainte Catherine (FR)
Publication Details
- Journal
- ESMO Gastrointestinal Oncology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.esmogo.2024.100106
- Citations
- 1
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Amgen
- Bristol-Myers Squibb
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Les Laboratories Pierre Fabre
- Seagen
- Astellas Pharma
- Servier
- Aptitude Health