Empagliflozin Attenuates Neointima Formation After Arterial Injury and Inhibits Smooth Muscle Cell Proliferation and Migration by Suppressing Platelet‐Derived Growth Factor–Related Signaling
This study highlights the crucial role of suppressing PDGF-related signaling in mediating the beneficial effects of empagliflozin on neointima formation and VSMC function, which are independent of SGLT2 and glycemic control. Our study provides a novel mechanistic aspect of empagliflozin for the prevention of vascular stenosis disorders.
Authors
- Wei‐Jan Chen (ORCID: https://orcid.org/0000-0001-8088-5475)
- Gwo‐Jyh Chang
- Yu‐Juei Hsu (ORCID: https://orcid.org/0000-0002-9696-612X)
- Ying‐Hwa Chen (ORCID: https://orcid.org/0000-0001-9321-8241)
Institutions
- Tri-Service General Hospital (TW)
- National Yang Ming Chiao Tung University (TW)
- Chang Gung University (TW)
- Taipei Veterans General Hospital (TW)
- Chang Gung Memorial Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1161/jaha.124.035044
- Citations
- 8
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.86