Orexin‐A Attenuates the Inflammatory Response in Sepsis‐Associated Encephalopathy by Modulating Oxidative Stress and Inhibiting the <scp>ERK</scp>/<scp>NF</scp>‐<scp>κB</scp> Signaling Pathway in Microglia and Astrocytes
Our data suggest that orexin-A reduces ROS expression by inhibiting CLP-induced NOX2 production, thereby attenuating mitochondrial damage and neuronal apoptosis. Its inhibition of microglial and A1-type astrocyte activation and inflammation was associated with the ERK/NF-κB pathway. These suggest that orexin-A may reduce cognitive impairment in SAE by reducing oxidative stress-induced inflammation.
Authors
- Tao Xiong (ORCID: https://orcid.org/0000-0003-3933-9119)
- Guoqiang Han
- Sha Yang
- Chaofei Chen (ORCID: https://orcid.org/0000-0003-3711-0812)
- Dexun Kong (ORCID: https://orcid.org/0009-0003-4429-8718)
- Jiqin Zhang (ORCID: https://orcid.org/0000-0001-9545-9532)
- Jinhai Lan
- Mei Deng
- Liangzhao Chu (ORCID: https://orcid.org/0000-0003-2289-7624)
- Jingjing Da (ORCID: https://orcid.org/0000-0002-2856-5041)
- Jian Luo (ORCID: https://orcid.org/0000-0003-3583-0154)
- Fang Wang (ORCID: https://orcid.org/0000-0002-4781-8673)
- Jian Liu (ORCID: https://orcid.org/0000-0002-5968-4318)
- Jing Guo (ORCID: https://orcid.org/0000-0002-4345-1800)
- Ying Tan (ORCID: https://orcid.org/0000-0001-8792-5396)
- Zhuo Kong
Institutions
- Guiyang Medical University (CN)
- Anshun University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Guizhou Provincial People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1111/cns.70096
- Citations
- 14
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 4.80
Funders
- National Natural Science Foundation of China