Distinctive grade based on Ki67 index and immune microenvironment of metastatic pancreatic neuroendocrine tumors responding to capecitabine plus temozolomide
Grade based on Ki67 index and immune environment change in PanNET patients responding well to CapTem. Patients with downgraded had longer mPFS compared to those with upgraded. It is necessary to reassess the Ki67 index after CapTem treatment, even in patients responding well to CapTem.
Authors
- Shunrong Ji (ORCID: https://orcid.org/0000-0003-2556-3320)
- Heli Gao (ORCID: https://orcid.org/0000-0001-6094-5776)
- Jin Xu (ORCID: https://orcid.org/0000-0002-2942-8604)
- Jie Chen (ORCID: https://orcid.org/0000-0002-0110-1706)
- Qifeng Zhuo (ORCID: https://orcid.org/0000-0003-0248-331X)
- Yi Qin (ORCID: https://orcid.org/0000-0001-9804-202X)
- Wuhu Zhang (ORCID: https://orcid.org/0000-0002-5182-9850)
- Xianjun Yu (ORCID: https://orcid.org/0000-0002-6697-7143)
- Zheng Li (ORCID: https://orcid.org/0000-0002-6141-4990)
- Xiaowu Xu (ORCID: https://orcid.org/0000-0001-5792-9839)
- Wensheng Liu (ORCID: https://orcid.org/0000-0001-9621-2742)
- Wenyan Xu (ORCID: https://orcid.org/0000-0003-1855-6245)
- Chenjie Zhou (ORCID: https://orcid.org/0000-0002-8774-6846)
- Yihua Shi (ORCID: https://orcid.org/0000-0001-8987-3542)
- Mengqi Liu (ORCID: https://orcid.org/0000-0001-9576-6903)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s12885-024-13117-5
- Citations
- 3
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Science and Technology Commission of Shanghai Municipality
- Shanghai Hospital Development Center