Enhanced antifungal activity of siRNA-loaded anionic liposomes against the human pathogenic fungus <i>Aspergillus fumigatus</i>
We developed siRNA-loaded anionic liposomes, co-encapsulating low-dose amphotericin B, to enhance siRNA penetration through the fungal cell wall of <i>Aspergillus fumigatus</i>. Targeting mRNAs of three key genes, these liposomes visibly inhibited fungal growth, demonstrating for the first time the antifungal potential of siRNA against human fungal pathogens.
Authors
- Jürgen Gröll (ORCID: https://orcid.org/0000-0003-3167-8466)
- Krystyna Albrecht
- Yidong Yu (ORCID: https://orcid.org/0000-0002-2845-1175)
- Andreas Beilhack (ORCID: https://orcid.org/0000-0002-3165-2648)
- Theresa Vogel
- Sina Hirsch
Institutions
- University of Würzburg (DE)
- Universitätsklinikum Würzburg (DE)
- Teikyo University (JP)
Publication Details
- Journal
- Nanoscale
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1039/d4nr03225j
- Citations
- 2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Deutsche Forschungsgemeinschaft
- Julius-Maximilians-Universität Würzburg
- Bayerisches Staatsministerium für Wissenschaft und Kunst
- Japan Society for the Promotion of Science
- Graduate School of Life Sciences, Julius-Maximilians-Universität Würzburg