1‐(2’‐Hydroxy‐2’‐Methylpropionyl)Glycoside as a Versatile Glycosyl Donor for <i>O</i>‐/<i>C</i>‐Glycosylation

Herein, we developed a Lewis acid-mediated O-glycosylation and C-glycosylation protocol using stable glycosyl 2'-hydroxy-2'-methylpropionates as donors. These glycosylation reactions reached completion within 1 h at room temperature. The practicality of this protocol is characterized by their straightforward operation and efficient applicability to various substrates, including both disarmed and armed glycosyl donors, through the remote activation of easily accessible TMSOTf.

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Publication Details

Journal
Chemistry - A European Journal
Published
2024-11-07
DOI
https://doi.org/10.1002/chem.202403534
Citations
2
Primary Topic
Carbohydrate Chemistry and Synthesis
Type
article
Field-Weighted Citation Impact
0.50
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article

1‐(2’‐Hydroxy‐2’‐Methylpropionyl)Glycoside as a Versatile Glycosyl Donor for O‐/C‐Glycosylation

Xin‐Shan Ye, De‐Cai Xiong, Hui Xiao, Miao Liu et al.
2 citations
Chemistry - A European Journal
Carbohydrate Chemistry and Synthesis
0.50
article

1‐(2’‐Hydroxy‐2’‐Methylpropionyl)Glycoside as a Versatile Glycosyl Donor for O‐/C‐Glycosylation

Xin‐Shan Ye, De‐Cai Xiong, Hui Xiao, Miao Liu, Liu Fen, Pengyu Wang, Meng Liu
article en
2 citations

Abstract

Herein, we developed a Lewis acid-mediated O-glycosylation and C-glycosylation protocol using stable glycosyl 2'-hydroxy-2'-methylpropionates as donors. These glycosylation reactions reached completion within 1 h at room temperature. The practicality of this protocol is characterized by their straightforward operation and efficient applicability to various substrates, including both disarmed and armed glycosyl donors, through the remote activation of easily accessible TMSOTf.

Chemistry - A European JournalVol. 31(5)
China Pharmaceutical University (CN), Peking University (CN), State Key Laboratory of Natural and Biomimetic Drugs (CN)
Openalex Percentile: Top 38%
Carbohydrate Chemistry and Synthesis
0.50
DOISourceOpenAlex
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1‐(2’‐Hydroxy‐2’‐Methylpropionyl)Glycoside as a Versatile Glycosyl Donor for <i>O</i>‐/<i>C</i>‐Glycosylation — Xin‐Shan Ye, De‐Cai Xiong, et al. · Chemistry - A European Journal (2024) | TGRS Research Map | TGRS