Inhibition of SGLT2 protects podocytes in diabetic kidney disease by rebalancing mitochondria-associated endoplasmic reticulum membranes
Inhibition of SGLT2 attenuates MAMs imbalance in diabetic podocytes by activating the AMPK pathway. This study expands our knowledge of the roles of SGLT2 inhibitors in improving DKD podocyte injury and provides new insights into DKD treatment.
Authors
- Shicong Song
- Sirui Liu (ORCID: https://orcid.org/0000-0003-4526-7924)
- Qinglan Yang (ORCID: https://orcid.org/0000-0003-1531-8110)
- Wei Zou (ORCID: https://orcid.org/0000-0001-5307-4685)
- Qiong Li (ORCID: https://orcid.org/0000-0002-8915-8781)
- Xue Li (ORCID: https://orcid.org/0000-0003-4836-7808)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-1590-7954)
- Shuangqin Chen (ORCID: https://orcid.org/0000-0001-8092-2125)
- Xinying Jiang
Institutions
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s12964-024-01914-1
- Citations
- 19
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 10.88
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province