FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression
Our results demonstrate FXR1's oncogenic involvement in ESCA cell lines, suggesting that FXR1 may be implicated in ESCA development by regulating the stability of PDZK1IP1 and ATOH8 mRNAs. For the first time, our findings emphasize the importance of FXR1-PDZK1IP1 and -ATOH8 functional modules in the development of ESCA, which might have potential diagnostic or therapeutic implications.
Authors
- Na Fang (ORCID: https://orcid.org/0000-0002-9628-0208)
- Dalia Fouad (ORCID: https://orcid.org/0000-0002-8191-0895)
- Farid Shokry Ataya (ORCID: https://orcid.org/0000-0002-0981-7805)
- Shaoping Ji (ORCID: https://orcid.org/0000-0003-1078-1819)
- Jingcheng Dong (ORCID: https://orcid.org/0000-0002-5194-367X)
- Faiz Ali Khan (ORCID: https://orcid.org/0000-0002-0867-2181)
Institutions
- Henan University (CN)
- Fudan University (CN)
- King Saud University (SA)
- Shaukat Khanum Memorial Cancer Hospital and Research Center (PK)
- Huashan Hospital (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s13062-024-00553-3
- Citations
- 14
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- National Natural Science Foundation of China
- King Saud University