Iron(II)-Catalyzed Synthesis of Nitrated Dihydropyrazole via a Nitrification and C–H Activation/Cyclization Cascade Reaction
A route for nitrification and C-H activation/cyclization of (<i>E</i>)-<i>N</i>-allyl-<i>N</i>'-benzylidenebenzenesulfonohydrazide and cobalt nitrate via an iron(II)-catalyzed cascade reaction to synthesize nitrated dihydropyrazoles has been developed. The method features convenient operation and good functional group tolerance. In addition, it employs insensitive and inexpensive FeSO<sub>4</sub> as the catalyst and provides a direct approach for the preparation of dihydropyrazoles.
Authors
- Chengcai Xia (ORCID: https://orcid.org/0000-0002-1943-5720)
- Changji Liu
- Guirong You (ORCID: https://orcid.org/0009-0002-0232-6808)
- Jiacheng Sun (ORCID: https://orcid.org/0009-0008-0133-7867)
- Wenjing Yang
- Mei Zhang (ORCID: https://orcid.org/0000-0001-6221-6315)
- Weibo Cheng
- Yi Liu (ORCID: https://orcid.org/0000-0001-5944-6005)
- Xi Zhang (ORCID: https://orcid.org/0009-0007-1790-5884)
Institutions
- Shandong First Medical University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1021/acs.joc.4c00313
- Citations
- 6
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Medical and Health Science and Technology Development Project of Shandong Province