Pancreatic cancer surveillance: Risk stratification of individuals with a germline <i>CDKN2A</i> pathogenic variant
Our study highlights the high lifetime risk of PDAC in carriers of a CDKN2A PV. While identifying significant risk factors such as family history of PDAC and smoking, our prediction model shows limited precision, highlighting the need for additional factors such as biomarkers to improve its clinical utility for tailored surveillance of high-risk individuals.
Authors
- Jihane Meziani (ORCID: https://orcid.org/0009-0000-4205-6860)
- Merel van Diepen (ORCID: https://orcid.org/0000-0003-3211-9500)
- Derk C.F. Klatte (ORCID: https://orcid.org/0000-0003-2531-6725)
- Marco J. Bruno (ORCID: https://orcid.org/0000-0001-9181-5499)
- Djuna L. Cahen (ORCID: https://orcid.org/0000-0001-6753-4857)
- Monique Esther van Leerdam (ORCID: https://orcid.org/0000-0002-5719-3208)
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- The Netherlands Cancer Institute (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1002/ueg2.12662
- Citations
- 5
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Universiteit Leiden
- Nierstichting
- Leids Universitair Medisch Centrum