Genetic and immunologic features associated with thrombocytopenia progression and poor prognosis in patients with myelofibrosis
<i>ASXL1</i> mutation and low CD45RA<sup>+</sup>CD4<sup>+</sup> T-cell counts correlated with progression to thrombocytopenia. Our findings underscore the clinical significance of thrombocytopenia dynamics in MF progression and prognosis, with implications for patient management and therapeutic interventions.
Authors
- Myungshin Kim (ORCID: https://orcid.org/0000-0001-8632-0168)
- Sung‐Eun Lee (ORCID: https://orcid.org/0000-0002-9810-2050)
- Ji Yoon Lee (ORCID: https://orcid.org/0000-0002-7117-2681)
- Jong‐Mi Lee (ORCID: https://orcid.org/0000-0003-2890-5285)
- Tong Yoon Kim (ORCID: https://orcid.org/0000-0002-9559-992X)
- Ki-Seong Eom
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
- The Catholic University of Korea Yeouido St. Mary's Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3389/fmed.2024.1461421
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea