Fusobacterium Nucleatum Aggravates Intestinal Barrier Impairment and Colitis Through IL-8 Induced Neutrophil Chemotaxis by Activating Epithelial Cells
<i>F. nucleatum</i> improves NE chemotaxis by infecting intestinal epithelial cells (IECs) to secrete IL-8 and aggravate intestinal barrier impairment, contributing to the progression of intestinal inflammation. Examining and eliminating <i>F. nucleatum</i> could be a valuable microbiome-based method for IBD surveillance and prevention.
Authors
- Boding Wang
- Shang Shi (ORCID: https://orcid.org/0000-0002-3315-1433)
- Yang Liu (ORCID: https://orcid.org/0000-0001-5553-3646)
- Bowen Li (ORCID: https://orcid.org/0000-0003-1550-4087)
- Yu Chen (ORCID: https://orcid.org/0000-0001-7387-1198)
- Lei Bao (ORCID: https://orcid.org/0000-0002-7834-4327)
- Jinhua Yang
- Fangqi Xu
- Wanlu Chen (ORCID: https://orcid.org/0000-0001-7471-416X)
- Zhiyue Wang (ORCID: https://orcid.org/0009-0002-9813-7138)
Institutions
- Ningbo University (CN)
- University of Nottingham Ningbo China (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/jir.s470376
- Citations
- 11
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province