Development of polymeric aptamer probes for <i>in vivo</i> continuous precision cancer targeting
The application of aptamers in biomedicine faces a significant challenge due to rapid degradation by nucleases. This study presents an innovative strategy for engineering polymeric aptamer probes with enhanced stability against degradation, improved binding affinity and internalization capability.
Authors
- Qiang Guo (ORCID: https://orcid.org/0009-0002-0644-350X)
- Xiaojing Zhang (ORCID: https://orcid.org/0000-0002-0595-3500)
- Yuting He (ORCID: https://orcid.org/0000-0002-9779-6863)
- Xue‐Qiang Wang (ORCID: https://orcid.org/0000-0003-1631-9158)
- Silin Huang (ORCID: https://orcid.org/0000-0001-8040-9356)
Institutions
- Kunming University of Science and Technology (CN)
- Hunan University (CN)
- First People's Hospital of Yunnan Province (CN)
- State Key Laboratory of Chemobiosensing and Chemometrics (CN)
Publication Details
- Journal
- Materials Chemistry Frontiers
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1039/d4qm00731j
- Citations
- 2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Natural Science Foundation for Distinguished Young Scholars of Hunan Province