Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis
The upregulation of ENAH through a PI3K/AKT/β-catenin signaling cascade enhances oral cancer cell migration and growth via the ITGB5/Src axis. These findings offer a new interpretation of the ENAH function in the OSCC progression and provide crucial information for developing new OSCC treatment strategies.
Authors
- Kai-Ping Chang (ORCID: https://orcid.org/0000-0002-9547-8327)
- Chiao‐Rou Liu
- Chu-Mi Hung
- Chia-Yu Yang (ORCID: https://orcid.org/0000-0002-5123-0856)
- Chih‐Ching Wu (ORCID: https://orcid.org/0000-0002-7264-9672)
- Hao‐Ping Liu (ORCID: https://orcid.org/0000-0001-5915-5128)
- Xiu‐Ya Chan
- Chun-Chueh Huang
Institutions
- Chang Gung University of Science and Technology (TW)
- National Chung Hsing University (TW)
- Chang Gung University (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s11658-024-00651-0
- Citations
- 11
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Chang Gung University
- Chang Gung Medical Foundation
- Chang Gung Memorial Hospital, Linkou
- National Science and Technology Council