Improved resolution of avian influenza virus using Oxford Nanopore R10 sequencing chemistry
This study demonstrates significant advancement in the field of influenza virus genomic surveillance by showcasing the superior accuracy and data quality of the Oxford Nanopore R10 sequencing chemistry compared to the older R9 chemistry. Improved resolution, including in the critical hemagglutinin multi-basic cleavage site, enables more reliable monitoring and tracking of viral mutations. This accelerates the ability to respond quickly to outbreaks, potentially improving impacts on public health, agriculture, and the economy by enabling more accurate and timely interventions.
Authors
- Hannah Gooden
- Peter Thielen (ORCID: https://orcid.org/0000-0003-1807-2785)
- Sonita Kol
- Erik A. Karlsson (ORCID: https://orcid.org/0000-0001-6004-5671)
- Abhinaya Srikanth
- Sokhoun Yann
- Brian Merritt
- Jeremy D. Ratcliff (ORCID: https://orcid.org/0000-0001-6522-138X)
- Songha Tok
- Jurre Y. Siegers (ORCID: https://orcid.org/0000-0002-0246-7830)
- Sarath Sin
Institutions
- Johns Hopkins University Applied Physics Laboratory (US)
- Institut Pasteur du Cambodge (KH)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1128/spectrum.01880-24
- Citations
- 8
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.09