Improved resolution of avian influenza virus using Oxford Nanopore R10 sequencing chemistry

This study demonstrates significant advancement in the field of influenza virus genomic surveillance by showcasing the superior accuracy and data quality of the Oxford Nanopore R10 sequencing chemistry compared to the older R9 chemistry. Improved resolution, including in the critical hemagglutinin multi-basic cleavage site, enables more reliable monitoring and tracking of viral mutations. This accelerates the ability to respond quickly to outbreaks, potentially improving impacts on public health, agriculture, and the economy by enabling more accurate and timely interventions.

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Publication Details

Journal
Microbiology Spectrum
Published
2024-11-07
DOI
https://doi.org/10.1128/spectrum.01880-24
Citations
8
Primary Topic
Influenza Virus Research Studies
Type
article
Field-Weighted Citation Impact
3.09
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article

Improved resolution of avian influenza virus using Oxford Nanopore R10 sequencing chemistry

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8 citations
Microbiology Spectrum
Influenza Virus Research Studies
3.09
article

Improved resolution of avian influenza virus using Oxford Nanopore R10 sequencing chemistry

Hannah Gooden, Peter Thielen, Sonita Kol, Erik A. Karlsson, Abhinaya Srikanth, Sokhoun Yann, Brian Merritt, Jeremy D. Ratcliff, Songha Tok, Jurre Y. Siegers, Sarath Sin
article en
8 citations

Abstract

This study demonstrates significant advancement in the field of influenza virus genomic surveillance by showcasing the superior accuracy and data quality of the Oxford Nanopore R10 sequencing chemistry compared to the older R9 chemistry. Improved resolution, including in the critical hemagglutinin multi-basic cleavage site, enables more reliable monitoring and tracking of viral mutations. This accelerates the ability to respond quickly to outbreaks, potentially improving impacts on public health, agriculture, and the economy by enabling more accurate and timely interventions.

Microbiology SpectrumVol. 12(12)
Johns Hopkins University Applied Physics Laboratory (US), Institut Pasteur du Cambodge (KH)
Zero hunger
Openalex Percentile: Top 7%
Influenza Virus Research Studies
3.09
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