IL-36 Gamma: A Novel Adjuvant Cytokine Enhancing Protective Immunity Induced by DNA Immunization with TGIST and TGNSM Against Toxoplasma gondii Infection in Mice
TgIST and TgNSM induce effective immunity against <i>T. gondii</i> infection, making them promising vaccine candidates against toxoplasmosis. Additionally, IL-36γ is a promising genetic adjuvant that enhances protective immunity in a vaccine setting against <i>T. gondii</i>, and it should be evaluated in strategies against other apicomplexan parasites.
Authors
- Jingfang Mu (ORCID: https://orcid.org/0000-0002-9005-2503)
- Ying Ching Tan (ORCID: https://orcid.org/0000-0003-2957-0165)
- Jia Chen (ORCID: https://orcid.org/0000-0001-6608-1518)
Institutions
- Ningbo University (CN)
- Ningbo University Affiliated Hospital (CN)
Publication Details
- Journal
- Microorganisms
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3390/microorganisms12112258
- Citations
- 6
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Ningbo University
- Chinese Academy of Agricultural Sciences
- State Key Laboratory of Veterinary Etiological Biology
- Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
- Natural Science Foundation of Zhejiang Province