Comparison of Analgesic and Anti-Inflammatory Effects of Kale Extract Versus Ibuprofen After Impacted Mandibular Third Molar Surgery: A Randomized, Double-Blind Split-Mouth Clinical Trial
The kale extract was more effective than ibuprofen. MMP-9 and TGF-β<sub>2</sub> levels were reduced on days 4 and 7 following the two extractions in the kale group, whereas they were reduced on days 4 and 7 following the first extraction in the ibuprofen group. There was a positive correlation between MMP-9 and TGF-β<sub>2</sub>. Thus, the consumption of the kale extract exerted analgesic and anti-inflammatory effects during the postoperative period in patients who had undergone molar extractions. In conclusion, anthocyanin-abundant kale extract is preferable when administered in a postoperative course and could reduce the need for a prescription of ibuprofen.
Authors
- Wachiraporn Tipsuwan
- Somdet Srichairatanakool (ORCID: https://orcid.org/0000-0002-5706-8781)
- Pimpisid Koonyosying (ORCID: https://orcid.org/0000-0002-6119-7009)
- Narisara Paradee (ORCID: https://orcid.org/0000-0001-5863-2404)
- Vuttinun Chatupos
- Sansanee Neelawatanasook
- Tidanut Sangutai
- Atit Khanutwong
- Pattaranee Srichairatanakool
- Onsaya Kerdto (ORCID: https://orcid.org/0009-0003-6058-1169)
Institutions
- University of Phayao (TH)
- Chiang Mai University (TH)
Publication Details
- Journal
- Nutrients
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3390/nu16223821
- Citations
- 3
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- Royal Project Foundation