Methotrexate inhibits glucocorticoids-induced osteoclastogenesis via activating IFN-γR/STAT1 pathway in the treatment of rheumatoid arthritis
Our study provides compelling evidence that MTX can make GCs effectively to suppress synovitis and reduce bone loss induced by GCs. This sheds light on the potential mechanistic insights underlying the efficacy of GCs in conjunction with MTX for treating RA.
Authors
- Ruizhi Feng
- Haifeng Yin (ORCID: https://orcid.org/0000-0001-7042-7630)
- Guo‐Min Deng (ORCID: https://orcid.org/0000-0001-7488-1304)
- 要子 伊藤 (ORCID: https://orcid.org/0000-0001-6877-5417)
- Wenlin Qiu
- Xiaoru Duan
- Xuefei Wang
- Li-Juan Jiang
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- RMD Open
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/rmdopen-2024-004886
- Citations
- 6
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Natural Science Foundation of China