Body mass index and type 2 diabetes mellitus as metabolic determinants of immune checkpoint inhibitors response in melanoma
In patients with melanoma treated with ICIs, being overweight had better survival outcomes compared with non-overweight. Having T2DM was associated with worse survival compared with those without T2DM. Further studies are needed to investigate the underlying mechanisms of these associations.
Authors
- Cho‐Han Chiang (ORCID: https://orcid.org/0000-0002-5757-6161)
- Ryan J. Sullivan (ORCID: https://orcid.org/0000-0001-5344-6645)
- Kerry L. Reynolds (ORCID: https://orcid.org/0000-0002-7793-654X)
- Yu Jen Jan (ORCID: https://orcid.org/0000-0002-2962-2933)
- Soravis Osataphan (ORCID: https://orcid.org/0000-0002-6503-4418)
- Aleigha Lawless (ORCID: https://orcid.org/0009-0009-3861-3164)
Institutions
- Mount Auburn Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/jitc-2024-009769
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.41