Targeted proteomics in extracellular vesicles identifies biomarkers predictive for therapeutic response in sarcoidosis
This study is the first to show that in pulmonary sarcoidosis the response to treatment with prednisone or MTX can be predicted at baseline by different EV proteins active in different pathways. Using these markers and associated pathways to identify patients with a high probability of response to therapy will aid personalised treatment choice and improve treatment outcome.
Authors
- Marcel Veltkamp (ORCID: https://orcid.org/0000-0001-7973-1604)
- Ioanna Paspali
- Jan C. Grutters (ORCID: https://orcid.org/0000-0003-3670-8097)
- Dominique P.V. de Kleijn (ORCID: https://orcid.org/0000-0003-2714-2140)
- Raisa Kraaijvanger (ORCID: https://orcid.org/0000-0001-5867-0750)
- Montse Janssen Bonás
- Coline H.M. van Moorsel
Institutions
- University Medical Center Utrecht (NL)
- St. Antonius Ziekenhuis (NL)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1183/23120541.00672-2024
- Citations
- 6
- Primary Topic
- Sarcoidosis and Beryllium Toxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- Longfonds