Fluvastatin suppresses hemin-induced cell death, reactive oxygen species generation, and elevated labile iron pool
The safety of statins is well established. When used in combination with fluvastatin or other statins, the suppressive effects of deferasirox on hemin-induced cytotoxicity in THP-1 cells were amplified. Further research is necessary to see whether statins will act in the same way in vivo or in human primary monocytes/macrophages.
Authors
- Katsuyasu Saigo (ORCID: https://orcid.org/0000-0001-9181-3194)
- Mari Kono (ORCID: https://orcid.org/0000-0002-7646-9118)
- Shion Imoto (ORCID: https://orcid.org/0000-0001-9490-5692)
- Yuji Mizokoshi
- Ayako Ohbuchi
- Tohru Sawamura
- Takashi Suzuki (ORCID: https://orcid.org/0000-0002-4697-8392)
Institutions
- Himeji Dokkyo University (JP)
- Kobe Tokiwa University (JP)
- University of Hyogo (JP)
- Himeji University (JP)
- University of Asia Pacific (BD)
Publication Details
- Journal
- Hematology Transfusion and Cell Therapy
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.htct.2024.09.2480
- Citations
- 2
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.91