Huaxian formula prevents the progression of radiation-induced pulmonary fibrosis by inhibiting the pro-fibrotic effects of macrophages
HXF's preventive effects on RIPF involve multiple targets and mechanisms, including the modulation of Arg1, Mmp10, and Fgf23 expression. By inhibiting the pro-fibrotic capacity of macrophages, HXF suppresses fibroblast activation and collagen production, thereby alleviating lung fibrosis. These findings underscore the potential of HXF as a preventive strategy in managing RIPF.
Authors
- Zengyi Fang
- Meihua Chen (ORCID: https://orcid.org/0000-0003-2813-7423)
- Pingjin Zou (ORCID: https://orcid.org/0000-0003-0480-5263)
- Jinyi Lang (ORCID: https://orcid.org/0000-0003-2394-4170)
- Caiping Gong
- Junyang Chen (ORCID: https://orcid.org/0009-0002-4724-1090)
- Bing Lin (ORCID: https://orcid.org/0009-0004-3486-0954)
- Quan Li (ORCID: https://orcid.org/0000-0002-0788-318X)
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan Cancer Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.jep.2024.119026
- Citations
- 2
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.81