Thyrotoxic Periodic Paralysis With Graves' Disease: A Case Report

One type of hypokalemic periodic paralysis that is associated with hyperthyroidism is called thyrotoxic periodic paralysis (TPP). TPP can be linked to any cause of hyperthyroidism, although Graves' disease is the most common cause. This sporadic variant of hypokalaemic periodic paralysis, thyrotoxic periodic paralysis, is characterized by rapid onset weakness in the proximal muscles. Due to their similar presentations, it is sometimes mistaken for familial periodic paralysis (FPP); however, biochemical tests and the presence of thyrotoxic characteristics can help distinguish the two conditions. Treatment options for this reversible illness include rapid potassium replacement and thyroid hormone normalization. To mitigate this potentially fatal complication, knowledge regarding the identification, prompt treatment, and avoidance of future episodes of TPP is crucial.

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Publication Details

Journal
Cureus
Published
2024-11-07
DOI
https://doi.org/10.7759/cureus.73223
Primary Topic
Ion channel regulation and function
Type
article
Field-Weighted Citation Impact
0.00
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article

Thyrotoxic Periodic Paralysis With Graves' Disease: A Case Report

Abin Thomas, Bilha Baby, T P Sreekrishnan, Gireesh Kumar K P et al.
Cureus
Ion channel regulation and function
article

Thyrotoxic Periodic Paralysis With Graves' Disease: A Case Report

Abin Thomas, Bilha Baby, T P Sreekrishnan, Gireesh Kumar K P, Shona Joy
article en

Abstract

One type of hypokalemic periodic paralysis that is associated with hyperthyroidism is called thyrotoxic periodic paralysis (TPP). TPP can be linked to any cause of hyperthyroidism, although Graves' disease is the most common cause. This sporadic variant of hypokalaemic periodic paralysis, thyrotoxic periodic paralysis, is characterized by rapid onset weakness in the proximal muscles. Due to their similar presentations, it is sometimes mistaken for familial periodic paralysis (FPP); however, biochemical tests and the presence of thyrotoxic characteristics can help distinguish the two conditions. Treatment options for this reversible illness include rapid potassium replacement and thyroid hormone normalization. To mitigate this potentially fatal complication, knowledge regarding the identification, prompt treatment, and avoidance of future episodes of TPP is crucial.

CureusVol. 16(11)
Amrita Institute of Medical Sciences and Research Centre (IN)
Good health and well-being
Openalex Percentile: Top 82%
Ion channel regulation and function
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