TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction

Our results uncover a novel mechanism of PD-1 regulation, and identify a pharmacologically tractable target whose inhibition suppresses PD-1 abundance and T cell dysfunction.

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Publication Details

Journal
Journal for ImmunoTherapy of Cancer
Published
2024-11-01
DOI
https://doi.org/10.1136/jitc-2024-010145
Citations
3
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.85

Funders

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article

TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction

Sanju Sinha, David W. Vredevoogd, Maarten Altelaar, Zowi R. Huinen et al.
3 citations
Journal for ImmunoTherapy of Cancer
Cancer Immunotherapy and Biomarkers
0.85
article

TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction

Sanju Sinha, David W. Vredevoogd, Maarten Altelaar, Zowi R. Huinen, Chun‐Pu Lin, Santiago Sánchez, Ettai Markovits, Susan E. van Hal-van Veen, Alex van Vliet, Nils L. Visser, Gal Markel, Michal J. Besser, Georgi Apriamashvili, Julia Boshuizen, Onno B. Bleijerveld, Pierre L. Levy, Oscar Krijgsman, Judit Díaz-Gómez, Daniel S. Peeper, Beaunelle de Bruijn, Maarten A. Ligtenberg, Juan Simon Nieto
article en
3 citations

Abstract

Our results uncover a novel mechanism of PD-1 regulation, and identify a pharmacologically tractable target whose inhibition suppresses PD-1 abundance and T cell dysfunction.

Journal for ImmunoTherapy of CancerVol. 12(11)
Tel Aviv University (IL), Utrecht University (NL), Sheba Medical Center (IL), Rabin Medical Center (IL), The Netherlands Cancer Institute (NL), Oncode Institute (NL), National Cancer Institute (US), Center for Cancer Research (US)
Nederlandse Organisatie voor Wetenschappelijk Onderzoek, KWF Kankerbestrijding, Oncode Institute, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 22%
Cancer Immunotherapy and Biomarkers
0.85
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