TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction
Our results uncover a novel mechanism of PD-1 regulation, and identify a pharmacologically tractable target whose inhibition suppresses PD-1 abundance and T cell dysfunction.
Authors
- Sanju Sinha (ORCID: https://orcid.org/0000-0002-2688-0603)
- David W. Vredevoogd (ORCID: https://orcid.org/0000-0001-6718-1422)
- Maarten Altelaar (ORCID: https://orcid.org/0000-0001-5093-5945)
- Zowi R. Huinen
- Chun‐Pu Lin (ORCID: https://orcid.org/0000-0001-5874-8001)
- Santiago Sánchez (ORCID: https://orcid.org/0000-0002-8027-7661)
- Ettai Markovits (ORCID: https://orcid.org/0000-0001-9817-0638)
- Susan E. van Hal-van Veen (ORCID: https://orcid.org/0000-0002-4196-133X)
- Alex van Vliet
- Nils L. Visser
- Gal Markel (ORCID: https://orcid.org/0000-0003-4835-891X)
- Michal J. Besser (ORCID: https://orcid.org/0000-0002-9233-0458)
- Georgi Apriamashvili (ORCID: https://orcid.org/0000-0003-3261-7921)
- Julia Boshuizen (ORCID: https://orcid.org/0000-0002-8135-0525)
- Onno B. Bleijerveld (ORCID: https://orcid.org/0000-0002-9395-2347)
- Pierre L. Levy (ORCID: https://orcid.org/0000-0003-3213-0080)
- Oscar Krijgsman (ORCID: https://orcid.org/0000-0003-0825-3291)
- Judit Díaz-Gómez
- Daniel S. Peeper (ORCID: https://orcid.org/0000-0003-1293-3177)
- Beaunelle de Bruijn (ORCID: https://orcid.org/0000-0001-5488-3695)
- Maarten A. Ligtenberg (ORCID: https://orcid.org/0000-0002-0020-1043)
- Juan Simon Nieto (ORCID: https://orcid.org/0009-0008-3657-1725)
Institutions
- Tel Aviv University (IL)
- Utrecht University (NL)
- Sheba Medical Center (IL)
- Rabin Medical Center (IL)
- The Netherlands Cancer Institute (NL)
- Oncode Institute (NL)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/jitc-2024-010145
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- KWF Kankerbestrijding
- Oncode Institute
- National Cancer Institute