IL-9 sensitizes human TH2 cells to proinflammatory IL-18 signals in atopic dermatitis
Our data identify a novel IL-9/IL-18 axis that contributes to T<sub>H</sub>2 responses in AD. Our findings suggest that both IL-9 and IL-18 could represent upstream targets for future treatment of AD.
Authors
- Thomas Bjarnsholt (ORCID: https://orcid.org/0000-0002-8003-7414)
- Iben Frier Ruge (ORCID: https://orcid.org/0000-0003-3914-360X)
- Sanja Kežić (ORCID: https://orcid.org/0000-0002-1063-4547)
- Jacob Pontoppidan Thyssen (ORCID: https://orcid.org/0000-0003-3770-1743)
- Christina Hillig (ORCID: https://orcid.org/0000-0001-7447-547X)
- Michel Gilliet
- Angela Vallone
- Christoph Schlapbach (ORCID: https://orcid.org/0000-0003-0258-1243)
- Lennart Matthias Roesner (ORCID: https://orcid.org/0000-0001-6651-0458)
- Thomas Werfel (ORCID: https://orcid.org/0000-0001-6830-7672)
- Blaine Gabriel Fritz (ORCID: https://orcid.org/0000-0002-2085-894X)
- Nicole Bertschi (ORCID: https://orcid.org/0000-0002-4664-1634)
- Michael P. Menden (ORCID: https://orcid.org/0000-0003-0267-5792)
- Susanne Radonjic‐Hoesli (ORCID: https://orcid.org/0000-0002-5742-0765)
- Amalie Thorsti Møller Rønnstad (ORCID: https://orcid.org/0000-0001-9949-9726)
- Fabian Luther (ORCID: https://orcid.org/0000-0002-0669-9460)
- Dagmar Simon (ORCID: https://orcid.org/0000-0001-8965-9407)
- Stefanie Eyerich (ORCID: https://orcid.org/0000-0002-1166-2355)
- Jérémy Di Domizio (ORCID: https://orcid.org/0000-0002-6281-3918)
- Kathrin Thormann (ORCID: https://orcid.org/0000-0002-4486-3591)
- Stefanie Schärli (ORCID: https://orcid.org/0000-0001-9125-9445)
Institutions
- University of Copenhagen (DK)
- University Hospital of Bern (CH)
- Bispebjerg Hospital (DK)
- Copenhagen University Hospital (DK)
- Helmholtz Zentrum München (DE)
- Medizinische Hochschule Hannover (DE)
- Public Health Service of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- University of Lausanne (CH)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.jaci.2024.10.027
- Citations
- 12
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.42
Funders
- National Science Foundation
- Eli Lilly and Company
- Pfizer
- Sanofi
- University of Bern
- Regeneron Pharmaceuticals
- Incyte
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Coloplast
- LEO Pharma
- Sanofi Genzyme
- International Graduate School of Science and Engineering