Precision Dosing of Intravenous Tocilizumab: Development of Pharmacokinetic Model–Derived Tapering Strategies for Patients With Rheumatoid Arthritis
Tapering strategies were developed for intravenous tocilizumab, offering potential application in patients with RA who have reached low disease activity or remission, pending clinical validation. The developed strategies demonstrate that the tapering of tocilizumab should be approached more carefully and in smaller steps than that of TNFi.
Authors
- Gertjan Wolbink (ORCID: https://orcid.org/0000-0003-1924-7460)
- Femke Hooijberg (ORCID: https://orcid.org/0000-0003-3835-1300)
- Theo Rispens (ORCID: https://orcid.org/0000-0001-9600-1312)
- Zohra Layegh (ORCID: https://orcid.org/0000-0002-8245-9725)
- Thomas P. C. Dorlo (ORCID: https://orcid.org/0000-0003-3076-8435)
- Annick de Vries (ORCID: https://orcid.org/0000-0001-7570-473X)
- Maureen Leeuw (ORCID: https://orcid.org/0000-0003-3479-2125)
- Ori Elkayam (ORCID: https://orcid.org/0000-0001-9329-3639)
- Michael Twahier Nurmohamed (ORCID: https://orcid.org/0000-0002-6274-1934)
- Stefan P. H. van den Berg
Institutions
- Uppsala University (SE)
- Tel Aviv Sourasky Medical Center (IL)
- Erasmus MC (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Sanquin (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1097/ftd.0000000000001258
- Citations
- 2
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.94