Molecular basis for the disease-modifying effects of belimumab in systemic lupus erythematosus and molecular predictors of early response: blood transcriptome analysis implicates the innate immunity and DNA damage response pathways
Belimumab treatment ameliorates multiple innate and adaptive immunity dysregulations of SLE and may reverse the disease signature, consistent with the drug effects on reducing activity and preventing flares. Fingerprints of innate immunity correlate with robust improvement whereas DNA damage response with less responsive disease to BAFF inhibition.
Authors
- Panagiotis Garantziotis
- George Sentis
- Myrto Nikoloudaki
- Anastasia Filia (ORCID: https://orcid.org/0000-0003-3824-2745)
- Nikolaos Malissovas
- Styliani Polia
- Dimitrios T. Boumpas (ORCID: https://orcid.org/0000-0002-9812-4671)
- George K Bertsias (ORCID: https://orcid.org/0000-0001-5299-1406)
- Noemin Kapsala (ORCID: https://orcid.org/0000-0002-6024-8185)
- Dionysis Nikolopoulos (ORCID: https://orcid.org/0000-0002-9894-6966)
- Georgia-Savina Moysidou (ORCID: https://orcid.org/0000-0002-7591-9797)
- Evgenia Stergioti
- Nikolaos Paschalidis (ORCID: https://orcid.org/0000-0001-6278-4144)
- Antonis Fanouriakis (ORCID: https://orcid.org/0000-0003-2696-031X)
- Spyridon Katechis (ORCID: https://orcid.org/0000-0002-8575-5183)
- Dimitra Nikoleri
- Maria Grigoriou (ORCID: https://orcid.org/0000-0001-5383-4138)
Institutions
- University of Crete (GR)
- Democritus University of Thrace (GR)
- National and Kapodistrian University of Athens (GR)
- Academy of Athens (GR)
- Karolinska Institutet (SE)
- Universitätsklinikum Erlangen (DE)
- FORTH Institute of Molecular Biology and Biotechnology (GR)
- University Hospital of Alexandroupolis (GR)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1136/ard-2024-226051
- Citations
- 16
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 7.52
Funders
- GlaxoSmithKline
- Deutsche Forschungsgemeinschaft
- European Research Council