Clinical and molecular characteristics associated with high PD-L1 expression in EGFR-mutated lung adenocarcinoma
High PD-L1 expression was more commonly found in lung adenocarcinomas with uncommon and complex EGFR mutations. Furthermore, high PD-L1 expression independently predicted poor survival. These findings warrant validation through prospective studies.
Authors
- Jennifer Arrondeau
- Audrey Mansuet‐Lupo (ORCID: https://orcid.org/0000-0002-7196-2114)
- J. Slomka (ORCID: https://orcid.org/0009-0008-0392-7801)
- Elizabeth Fabre (ORCID: https://orcid.org/0000-0002-1244-873X)
- Bastien Rance (ORCID: https://orcid.org/0000-0003-4417-1197)
- Gary Birsen (ORCID: https://orcid.org/0009-0007-3534-1007)
- Marie Wislez (ORCID: https://orcid.org/0000-0001-7518-7859)
- Marco Alifano
- Karen Leroy (ORCID: https://orcid.org/0000-0002-4379-0140)
- Hélène Blons (ORCID: https://orcid.org/0000-0002-0572-8426)
- Ivan Lerner (ORCID: https://orcid.org/0000-0002-5466-1707)
- Laure Gibault (ORCID: https://orcid.org/0000-0002-0791-074X)
- Hugo Berthou
- Jeanne Chapron (ORCID: https://orcid.org/0009-0001-0178-5861)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1371/journal.pone.0307161
- Citations
- 3
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.26