A Multicomponent [2+2+1] Cascade Cyclization to Synthesize Thiazol-2(3<i>H</i>)-one
A multicomponent [2+2+1] tandem cyclization of alkynones with amines and water using potassium thiocyanate as electrolyte and raw material to access thiazol-2(3<i>H</i>)-ones has been developed. This transformation proceeded smoothly via electrocatalytic oxidative C-H bond thiolation, and nucleophilic cascade cyclization to build the (C-S/C-N) bonds to construct the C-O bond. The reaction avoided using transition metal catalysts or oxidation reagents, making it more sustainable and renewable.
Authors
- Ganpeng Li (ORCID: https://orcid.org/0000-0001-5954-8757)
- Yonghui He (ORCID: https://orcid.org/0000-0001-6724-8607)
- Yuefa Gong (ORCID: https://orcid.org/0000-0001-9944-4055)
- Yuqi Shi (ORCID: https://orcid.org/0000-0002-1930-1423)
- Qinyu Zhao (ORCID: https://orcid.org/0000-0003-3543-7969)
- Xiaojing Zhao (ORCID: https://orcid.org/0000-0003-3018-5061)
- Mingxu Wang (ORCID: https://orcid.org/0009-0003-2850-5625)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1021/acs.joc.4c01800
- Citations
- 3
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Applied Basic Research Key Project of Yunnan