Clinicopathological features of colorectal cancer patients under 30 years of age

Background: Colorectal cancer (CRC) is the second cause of cancer death in the world and is estimated to have been responsible for almost 935,000 deaths during 2020.Objective: Describe clinicopathological features, overall survival (OS) and progression-free survival (PFS) in CRC patients under 30 years.Method: This is a retrospective cohort study in patients under 30 years diagnosed with CRC.Results: From 2017 to 2021, 1823 patients were diagnosed with CRC, of which 54 (2.96%) were under 30 years.The OS, during 4 years, was 41.5%.The clinical stage found IV (hazard ratio [HR]: 6.212; 95% confidence interval [95%CI]: 2.504-15.414;p < 0.001), giving neoadjuvant therapy (HR: 0.705; 95%CI: 0.499-0.996;p = 0.047) and no medical history of Lynch syndrome (HR: 3.925; 95%CI: 1.355-11.364;p = 0.012) are independent predictors of mortality.The PFS, during 4 years, was 21.3%.Clinical stage IV (HR: 2.418; 95%CI: 1.000-5.850;p < 0.050), and no diagnosis of Lynch syndrome (HR: 3.800; 95%CI: 1.398-10.326;p = 0.009) are independent predictors.Conclusions: Younger patients are usually diagnosed with CRC in advanced stages.Early symptoms and evaluation, irrespective of age, are crucial.