RIPK2 and lysosomal pathway: Unveiling a new mechanism for lung cancer metastasis
This study reveals for the first time that RIPK2 promotes lung cancer metastasis by inhibiting LAMP2 expression, thereby suppressing the lysosomal pathway and altering the tumor microenvironment. In the future, targeted therapy against RIPK2 and LAMP2 may become an effective means to inhibit lung cancer metastasis.
Authors
- Wei Xu (ORCID: https://orcid.org/0000-0002-8113-9746)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-6149-4054)
- Wei Liu (ORCID: https://orcid.org/0000-0003-0012-6845)
- Huifang Hao (ORCID: https://orcid.org/0000-0002-9680-8308)
- Lin Yang (ORCID: https://orcid.org/0000-0002-3509-0523)
- Bo Zhang (ORCID: https://orcid.org/0009-0002-9957-5914)
Institutions
- Hebei Medical University (CN)
- People's Hospital of Cangzhou (CN)
- First Hospital of Shijiazhuang (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1016/j.tranon.2024.102182
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.39