Copper-Catalyzed Asymmetric Radical Oxysulfonylation of 2-Vinylbenzoic Acids to Access Chiral Sulfonyl Phthalides

This study presents the development of a radical enantioselective alkene oxysulfonylation approach for the synthesis of enantioenriched sulfonyl phthalides via a catalyst system consisting of a copper salt and an OPPA ligand. The reaction proceeded under mild conditions with a wide range of substrates, good yields, and excellent enantioselectivities. Mechanistic studies suggested that the reaction proceeded through a radical-mediated process. Scalable synthesis and transformation experiments also demonstrated the applicable potential of this method.