Sodium Butyrate Inhibits Necroptosis by Regulating MLKL via E2F1 in Intestinal Epithelial Cells of Liver Cirrhosis
NaB alleviates intestinal mucosal injury and reduces necroptosis in IECs in liver cirrhosis. It also inhibits the necroptosis of IECs and protects the intestinal barrier by reducing E2F1 expression and downregulating MLKL expression levels. These results can be employed to develop a novel strategy for treating complications arising from liver cirrhosis.
Authors
- Yimeng Zhou (ORCID: https://orcid.org/0009-0001-9243-3270)
- Chong Zhang (ORCID: https://orcid.org/0000-0001-5322-1091)
- Yaoxin Fan
- Qiuju Sheng (ORCID: https://orcid.org/0000-0001-6683-9309)
- Xiaoguang Dou (ORCID: https://orcid.org/0000-0003-1856-7331)
- Chao Han (ORCID: https://orcid.org/0000-0001-8580-4697)
- Yang Ding
- Lu Bingchao
- Yanwei Li (ORCID: https://orcid.org/0009-0008-3939-6360)
- Ziyi Wang (ORCID: https://orcid.org/0000-0002-9604-0335)
Institutions
- China Medical University (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.14218/jcth.2024.00221
- Citations
- 1
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Shengjing Hospital