Associations of exposure to phthalate with serum uric acid and hyperuricemia risk, and the mediating role of systemic immune inflammation
Individual and mixture of urinary PAEs metabolites were associated with increased serum uric acid concentration and the risk of hyperuricemia. MBzP exhibited the highest contribution to the overall effects. SII alteration may be an important biological mechanism underlining the impact of PAEs metabolites on serum uric acid concentration and hyperuricemia risk.
Authors
- Wenyuan Yu (ORCID: https://orcid.org/0000-0002-2917-5993)
- Zhizhou Duan (ORCID: https://orcid.org/0000-0002-5014-5799)
- Wenpu Shao
- Zhiping Niu (ORCID: https://orcid.org/0000-0002-5204-7308)
- Yanyi Xu (ORCID: https://orcid.org/0000-0003-0270-2017)
- Shuang Du (ORCID: https://orcid.org/0009-0006-9820-3456)
- Yifan Shi (ORCID: https://orcid.org/0000-0001-6551-2697)
- Zhuohui Zhao (ORCID: https://orcid.org/0000-0001-8596-0278)
- Han Chen (ORCID: https://orcid.org/0000-0002-5912-3692)
- Hao Tang (ORCID: https://orcid.org/0000-0003-2202-0515)
- Tianyi Chen (ORCID: https://orcid.org/0000-0002-1611-1974)
- Shichao Han (ORCID: https://orcid.org/0000-0001-5404-7347)
- Jin Sun
- Yunfei Cai (ORCID: https://orcid.org/0000-0002-2249-860X)
Institutions
- Fudan University (CN)
- Wuhan University (CN)
- SAIC-GM (China) (CN)
- Shanghai Public Health Clinical Center (CN)
- Jiangxi Provincial People's Hospital (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2024.117269
- Citations
- 16
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 5.04