Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology
A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained whole slide images from the largest reported cohort to date. The model showed promising performance in identifying diagnostic category, grade, mitosis-karyorrhexis index (MKI), and MYCN-amplification with validation on an external test dataset, suggesting potential for AI-assisted neuroblastoma classification.
Authors
- Arlene Naranjo (ORCID: https://orcid.org/0000-0001-7737-4324)
- Rani E. George (ORCID: https://orcid.org/0000-0003-4206-1779)
- Nicole A. Cipriani (ORCID: https://orcid.org/0000-0003-3092-2746)
- Kritika Patel (ORCID: https://orcid.org/0009-0007-3569-294X)
- Hiroyuki Shimada (ORCID: https://orcid.org/0000-0001-5025-7507)
- Elizabeth Sokol (ORCID: https://orcid.org/0000-0002-1787-6901)
- James M. Dolezal (ORCID: https://orcid.org/0000-0002-6788-7203)
- Alexander T. Pearson (ORCID: https://orcid.org/0000-0003-2801-7456)
- Susan L. Cohn (ORCID: https://orcid.org/0000-0001-5749-7650)
- Peter Pytel (ORCID: https://orcid.org/0000-0001-9506-4709)
- Sara Kochanny (ORCID: https://orcid.org/0000-0003-3755-1175)
- Monica Pomaville (ORCID: https://orcid.org/0009-0008-0498-5544)
- Kristina Doytcheva (ORCID: https://orcid.org/0009-0003-8638-5895)
- Rachel TerHaar
- Mark A. Applebaum (ORCID: https://orcid.org/0000-0001-9766-8477)
- Siddhi Ramesh (ORCID: https://orcid.org/0000-0003-2225-4864)
- Aliya N. Husain (ORCID: https://orcid.org/0000-0001-5492-7387)
- Benjamin Kusswurm
- Casey J. Mehrhoff (ORCID: https://orcid.org/0009-0000-1097-2776)
- Emma Dyer (ORCID: https://orcid.org/0000-0002-5818-3589)
- Jacob Brewer
Institutions
- Intermountain Healthcare (US)
- Northwestern University (US)
- Boston Children's Hospital (US)
- Lurie Children's Hospital (US)
- Seattle Children's Hospital (US)
- Primary Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- University of Washington (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- University Medical Center (US)
- University of Oklahoma Medical Center (US)
- University of Florida (US)
- University of Chicago (US)
- Center for Cancer and Blood Disorders (US)
- Dana-Farber Cancer Institute (US)
- Children's Oncology Group (US)
- Geisinger Neuroscience Institute (US)
- Stanford University (US)
Publication Details
- Journal
- npj Precision Oncology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1038/s41698-024-00745-0
- Citations
- 11
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- University of Chicago
- National Institutes of Health
- Pritzker School of Medicine
- National Cancer Institute