Soluble and EV-bound CD27 act as antagonistic biomarkers in patients with solid tumors undergoing immunotherapy
Soluble and EV-bound CD27 appear to have opposing immunomodulatory functions and may represent easily measurable, non-invasive prognostic markers to predict response and survival in patients undergoing ICI therapy.
Authors
- Tom Luedde (ORCID: https://orcid.org/0000-0002-6288-8821)
- Julian Götze
- Gustav Buescher (ORCID: https://orcid.org/0000-0002-3865-5235)
- Paul Kachel (ORCID: https://orcid.org/0000-0002-9021-5309)
- Franziska Giehren
- Thais Pereira‐Veiga (ORCID: https://orcid.org/0000-0002-4473-7608)
- Kornelius Schulze (ORCID: https://orcid.org/0000-0001-7078-9260)
- Maria Geffken
- Tim H. Brümmendorf
- Francesca Pagani (ORCID: https://orcid.org/0000-0002-1671-5671)
- Sven Peine
- Lorenz Kocheise (ORCID: https://orcid.org/0000-0002-0036-2234)
- Christoph Roderburg (ORCID: https://orcid.org/0000-0002-1409-7697)
- Alina Busch
- Vincent Joerg
- Marcus Altfeld (ORCID: https://orcid.org/0000-0001-5972-2997)
- Joao Gorgulho (ORCID: https://orcid.org/0000-0003-1986-8208)
- Constantin Schmidt (ORCID: https://orcid.org/0000-0002-9906-9192)
- Urte Matschl
- Christina C. Rolling (ORCID: https://orcid.org/0000-0002-1001-8138)
- Sven H. Loosen (ORCID: https://orcid.org/0000-0003-3447-1161)
- Ansgar Wilhelm Lohse (ORCID: https://orcid.org/0000-0002-8823-3129)
- Fabian Beier (ORCID: https://orcid.org/0000-0002-3718-8217)
- Carsten Bokemeyer (ORCID: https://orcid.org/0000-0001-6071-7810)
- Harriet Wikman (ORCID: https://orcid.org/0000-0001-6862-0888)
- Ramsha Masood
- Britta Fritzsche (ORCID: https://orcid.org/0000-0002-2783-1512)
- Samuel Huber (ORCID: https://orcid.org/0000-0001-9325-8227)
- Simon Wehmeyer
- Marianne Sinn
- Johann von Felden
- B J Schmidt (ORCID: https://orcid.org/0009-0006-2902-9650)
- Eva Kinkel
Institutions
- Leibniz Institute of Virology (LIV) (DE)
- Universität Hamburg (DE)
- Düsseldorf University Hospital (DE)
- Integrated Oncology (United States) (US)
- University Medical Center Hamburg-Eppendorf (DE)
- University Cancer Center Hamburg (DE)
- ERN GUARD-Heart (NL)
- ERN RARE-LIVER (DE)
- Heinrich Heine University Düsseldorf (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1186/s13046-024-03215-4
- Citations
- 8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- Wilhelm Sander-Stiftung
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Deutsche Krebshilfe
- European Research Council
- Universitätsklinikum Hamburg-Eppendorf