KRASG12D-Mutated Metastatic Colorectal Cancer: Clinical, Molecular, Immunologic, and Prognostic Features of a New Emerging Targeted Alteration

A detail estimation of KRASG12D mut mCRC patients' characteristics and expected outcomes may be useful when planning future studies in this subgroup. The high prevalence of PI3K/PTEN/Akt pathway activating alterations may affect the efficacy of targeted strategies.

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Publication Details

Journal
JCO Precision Oncology
Published
2024-11-01
DOI
https://doi.org/10.1200/po.24.00329
Citations
2
Primary Topic
Colorectal Cancer Treatments and Studies
Type
article
Field-Weighted Citation Impact
0.57
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article

KRASG12D-Mutated Metastatic Colorectal Cancer: Clinical, Molecular, Immunologic, and Prognostic Features of a New Emerging Targeted Alteration

Marco Maria Germani, Rossana Intini, Maria Alessandra Calegari, Emiliano Tamburini et al.
2 citations
JCO Precision Oncology
Colorectal Cancer Treatments and Studies
0.57
article

KRASG12D-Mutated Metastatic Colorectal Cancer: Clinical, Molecular, Immunologic, and Prognostic Features of a New Emerging Targeted Alteration

Marco Maria Germani, Rossana Intini, Maria Alessandra Calegari, Emiliano Tamburini, Lisa Salvatore, Roberto Moretto, Guglielmo Vetere, Sara Lonardi, Sabina Murgioni, Gianluca Masi, Chiara Boccaccio, Vincenzo Nasca, Filippo Pietrantonio, Chiara Cremolini, Paolo Ciracì, Alessandro Passardi, Ada Taravella, Vittorio Studiale, Daniele Rossini, Alberto Zaniboni
article en
2 citations

Abstract

A detail estimation of KRASG12D mut mCRC patients' characteristics and expected outcomes may be useful when planning future studies in this subgroup. The high prevalence of PI3K/PTEN/Akt pathway activating alterations may affect the efficacy of targeted strategies.

JCO Precision OncologyVol. 8(8)
Università Cattolica del Sacro Cuore (IT), University of Pisa (IT), Agostino Gemelli University Polyclinic (IT), Ospedale di Cattinara (IT), Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT), Istituto Oncologico Veneto (IT), Fondazione Poliambulanza Istituto Ospedaliero (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), Azienda Ospedaliera Universitaria Pisana (IT), University of Florence (IT)
Good health and well-being
Openalex Percentile: Top 27%
Colorectal Cancer Treatments and Studies
0.57
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