Consent-Related Outcomes in the Alteplase Compared to Tenecteplase Trial
Deferral of consent was broadly acceptable to participants in the AcT trial as demonstrated by low rates of withdrawal and by survey results. Door-to-randomization times using deferral of consent in AcT were short, although a system of prospective verbal consent used at 1 center took only slightly longer. These results support the importance of innovation around consent for acute stroke trials.
Authors
- Aleksander Tkach (ORCID: https://orcid.org/0009-0009-4063-4431)
- Brian H Buck (ORCID: https://orcid.org/0000-0002-7984-6062)
- Mohammed Almekhlafi (ORCID: https://orcid.org/0000-0001-9550-8197)
- Brian Dewar (ORCID: https://orcid.org/0000-0002-9222-5420)
- Dar Dowlatshahi (ORCID: https://orcid.org/0000-0003-1379-3612)
- Michel Christopher Frank Shamy (ORCID: https://orcid.org/0000-0002-0085-6816)
- Nishita Singh (ORCID: https://orcid.org/0000-0003-3647-0904)
- Yan Deschaintre (ORCID: https://orcid.org/0000-0001-8778-3818)
- Laura C. Gioia (ORCID: https://orcid.org/0000-0001-7382-4973)
- Ayoola Ademola (ORCID: https://orcid.org/0000-0002-8412-6246)
- Luciana Catanese (ORCID: https://orcid.org/0000-0002-8696-5211)
- Bijoy K. Menon (ORCID: https://orcid.org/0000-0002-3466-496X)
- Tolulope T. Sajobi (ORCID: https://orcid.org/0000-0002-5696-5552)
- Carol Kenney
- Kayla D. Sage
- Richard H. Swartz (ORCID: https://orcid.org/0000-0001-6571-5531)
Institutions
- University of Ottawa (CA)
Publication Details
- Journal
- Neurology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1212/wnl.0000000000209974
- Citations
- 2
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.22