Platelet-derived mitochondria regulate lipid metabolism in nonalcoholic steatohepatitis through extracellular vesicles
We offer a novel molecular mechanism that connects platelets, pEVs, and excessive LD accumulation to the development of NASH. Our results suggest that NASH progression may be alleviated by specifically inhibiting the production and release of pEVs, or by targeting pEV components and inhibiting their uptake. Additional experiments are required to confirm this potentiality.
Authors
- Chung‐Hsin Chang
- Kuo‐Tung Tang (ORCID: https://orcid.org/0000-0002-5468-1329)
- Sheng‐Shun Yang
- Yi‐Ming Chen (ORCID: https://orcid.org/0000-0001-7593-3065)
- Tsai-Ling Liao
- Der-Yuan Chen
- Shie-Liang Hsieh
- Yingying Yang (ORCID: https://orcid.org/0000-0003-2919-9853)
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Chung Hsing University (TW)
- National Health Research Institutes (TW)
- China Medical University (TW)
- Taipei Veterans General Hospital (TW)
- Genomics Research Center, Academia Sinica (TW)
- Taichung Veterans General Hospital (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- Hepatology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1097/hep.0000000000001149
- Citations
- 6
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.32