Hemodynamic effects of carvedilol plus simvastatin in cirrhosis with severe portal hypertension and suboptimal response to β-blockers: A double-blind, placebo-controlled, randomized trial
In patients with severe portal hypertension (all with high-risk varices) and suboptimal hemodynamic response to traditional NSBBs, combined therapy with carvedilol plus simvastatin significantly enhances the portal pressure reduction achieved with carvedilol monotherapy, improves endothelial dysfunction, and reduces proinflammatory cytokines.
Authors
- Anna Brujats (ORCID: https://orcid.org/0000-0003-3317-0295)
- Ángela Puente (ORCID: https://orcid.org/0000-0002-8533-2412)
- Rosa Montañés
- Edilmar Alvarado‐Tápias (ORCID: https://orcid.org/0000-0003-2036-6133)
- Xavier Torras (ORCID: https://orcid.org/0000-0002-5662-5064)
- Álvaro García‐Osuna (ORCID: https://orcid.org/0000-0002-6682-0226)
- Elisabet Cantó (ORCID: https://orcid.org/0000-0002-1782-1855)
- Oana Pavel (ORCID: https://orcid.org/0009-0003-3442-9374)
- Carles Aracil (ORCID: https://orcid.org/0000-0002-8228-9041)
- Àngels Escorsell (ORCID: https://orcid.org/0000-0001-5083-8467)
- Alba Ardèvol (ORCID: https://orcid.org/0000-0001-8782-8035)
- Ainhoa Rodríguez‐Arias (ORCID: https://orcid.org/0009-0001-1826-6072)
- Javier Antonio Tamayo Fajardo (ORCID: https://orcid.org/0000-0002-0990-9718)
- Berta Cuyàs (ORCID: https://orcid.org/0000-0001-9988-7163)
- Marta Garcia‐Guix (ORCID: https://orcid.org/0009-0007-9384-9036)
- Càndid Villanueva
- María Poca (ORCID: https://orcid.org/0000-0002-0235-1395)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Institut de Recerca Sant Pau (ES)
Publication Details
- Journal
- Hepatology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1097/hep.0000000000001148
- Citations
- 13
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 4.80