Increased Rab1a accelerates osteoarthritis by inhibiting autophagy via activation of the mTORC1-S6K pathway
The augmentation of Rab1a expression impairs autophagy and promotes apoptosis through the activation of the mTORC1-S6K signaling pathway, further exacerbating OA pathogenesis. This finding suggests that Rab1a serves as a promising and innovative therapeutic target for the prevention and treatment of OA.
Authors
- Changhai Ding (ORCID: https://orcid.org/0000-0002-9479-730X)
- Yi-Shuan Lin
- Jianmao Chen
- Zhaohua Zhu (ORCID: https://orcid.org/0000-0003-3913-2564)
- Su’an Tang (ORCID: https://orcid.org/0000-0002-1391-5838)
- Ze Chen (ORCID: https://orcid.org/0000-0002-2871-8757)
- Cuixi Wu (ORCID: https://orcid.org/0009-0000-1405-9984)
- Yongming Liu
- Hong Huang (ORCID: https://orcid.org/0000-0002-0981-3628)
- Zhao Wu (ORCID: https://orcid.org/0000-0001-8545-7373)
- Weiyu Han (ORCID: https://orcid.org/0000-0003-1590-7433)
- Mingze Tang
Institutions
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.jare.2024.11.009
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Southern Medical University
- Basic and Applied Basic Research Foundation of Guangdong Province