Alanyl-Glutamine Inhibits the Epithelial-Mesenchymal Transition of Airway Epithelial Cells in Asthmatic Mice via DPP4-SIRT1 Pathway
Ala-Gln can inhibit BEC fibrosis and Th17 cell differentiation mediated by recombinant sCD26/sDPP4 through the SIRT1 pathway. Combined with BUD, Ala-Gln enhanced therapeutic efficacy in OVA-induced asthma in mice, which could offer improved outcomes for asthmatic patients with elevated DPP4 levels.
Authors
- Lu‐Hong Xu (ORCID: https://orcid.org/0000-0001-7898-7720)
- Kai Ding (ORCID: https://orcid.org/0000-0002-8202-0173)
- Libing Ma (ORCID: https://orcid.org/0000-0002-7234-2312)
- Dan Liang (ORCID: https://orcid.org/0000-0001-7363-4803)
- Lixia Hou (ORCID: https://orcid.org/0000-0002-2090-2859)
- Fei Xue (ORCID: https://orcid.org/0000-0002-5681-229X)
- Xiaowen He (ORCID: https://orcid.org/0009-0008-5205-9676)
- Xiao Bo
- Guiming Zhou
Institutions
- Guilin Medical University (CN)
Publication Details
- Journal
- International Archives of Allergy and Immunology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1159/000541681
- Citations
- 1
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.39