Effect of mepolizumab in airway remodeling in patients with late-onset severe asthma with an eosinophilic phenotype
This study identified that 12 months of mepolizumab treatment in patients with late-onset severe asthma, who are also characterized by eosinophilic and impaired reversibility phenotypes, not only leads to clinical improvement but also reduces indices of airway tissue remodeling suggestive of a disease-modifying effect.
Authors
- Andriana Ι. Papaioannou (ORCID: https://orcid.org/0000-0001-9708-3241)
- Κonstantinos Κatsoulis (ORCID: https://orcid.org/0000-0003-2432-183X)
- Stavros Τryfon (ORCID: https://orcid.org/0000-0001-5102-0480)
- Nikoleta Pastelli
- Evangelia Fouka (ORCID: https://orcid.org/0000-0003-4456-8987)
- Despoina Papakosta (ORCID: https://orcid.org/0000-0002-3465-3806)
- Theodora Papamitsou (ORCID: https://orcid.org/0000-0002-0709-5407)
- Κonstantinos Porpodis (ORCID: https://orcid.org/0000-0001-7215-2191)
- Νikoletta Ρovina (ORCID: https://orcid.org/0000-0003-0138-5582)
- Kalliopi Domvri (ORCID: https://orcid.org/0000-0002-4812-9108)
- Petros Bakakos (ORCID: https://orcid.org/0000-0001-9256-9656)
- Ioanna Tsiouprou (ORCID: https://orcid.org/0000-0001-8740-3504)
- Stelios Loukides (ORCID: https://orcid.org/0000-0002-4278-9922)
- Katerina M. Antoniou (ORCID: https://orcid.org/0009-0006-0207-4582)
- Paschalis Steiropoulos
- Κonstantinos Κostikas (ORCID: https://orcid.org/0000-0003-0774-3942)
- Paraskevi Κatsaounou (ORCID: https://orcid.org/0000-0002-8736-619X)
Institutions
- University of Crete (GR)
- Democritus University of Thrace (GR)
- University of Ioannina (GR)
- National and Kapodistrian University of Athens (GR)
- Aristotle University of Thessaloniki (GR)
- 424 General Military Hospital (GR)
- G. Papanikolaou General Hospital (GR)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.jaci.2024.10.024
- Citations
- 35
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 11.43
Funders
- Sierra Oncology