Polygenic Risk Scores and Hearing Loss Phenotypes in Children
In this cross-sectional study, a PRS initially developed for adult hearing difficulty was associated with wide-ranging childhood hearing loss phenotypes, partly explaining hearing phenotype variations despite shared genetic and environmental factors (eg, preterm birth). Large-scale studies with objectively defined hearing phenotypes are crucial for refining PRS and predicting high-risk children.
Authors
- Valerie Sung (ORCID: https://orcid.org/0000-0003-2029-6331)
- Daisy A. Shepherd (ORCID: https://orcid.org/0000-0001-8540-0473)
- Jing Wang (ORCID: https://orcid.org/0000-0001-5701-476X)
- Melissa A Wake (ORCID: https://orcid.org/0000-0001-7501-9257)
- Jessica A. Kerr (ORCID: https://orcid.org/0000-0002-3150-4047)
- Angela Tamsin Morgan (ORCID: https://orcid.org/0000-0003-1147-7405)
- Fan He (ORCID: https://orcid.org/0000-0001-5696-0631)
- Katherine Lange (ORCID: https://orcid.org/0000-0002-8175-6285)
- Richard Saffery (ORCID: https://orcid.org/0000-0002-9510-4181)
- Shuai Li (ORCID: https://orcid.org/0000-0002-8696-8594)
Institutions
- Royal Children's Hospital (AU)
- University of Auckland (NZ)
- The University of Melbourne (AU)
- La Trobe University (AU)
- University of Cambridge (GB)
- Monash Health (AU)
- Murdoch Children's Research Institute (AU)
- Monash University (AU)
- University of Otago (NZ)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1001/jamaoto.2024.3659
- Citations
- 3
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.08