ZIP7 contributes to the pathogenesis of diabetic cardiomyopathy by suppressing mitophagy in mouse hearts
ZIP7 upregulation mediates the inhibition of mitophagy by T2DM in mouse hearts by suppressing the PINK1/Parkin pathway. Reduction of mitochondrial Zn<sup>2+</sup> due to upregulation of ZIP7 accounts for the inhibition of the PINK1/Parkin pathway. Prevention of ZIP7 upregulation is essential for the treatment of T2DM-induced cardiomyopathy.
Authors
- Zhelong Xu (ORCID: https://orcid.org/0000-0003-0430-2906)
- Hualu Zhang
- Ningzhi Yang
- Rui Zhang (ORCID: https://orcid.org/0000-0001-9000-5021)
- Yonghao Yu (ORCID: https://orcid.org/0000-0002-7289-7748)
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s12933-024-02499-2
- Citations
- 13
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 4.02
Funders
- National Natural Science Foundation of China
- Tianjin Municipal Education Commission