Alkaloids and Styryl Lactones from <i>Goniothalamus tortilipetalus</i> and Their Biological Activities
Phytochemical investigations of the twig and leaf extracts of <i>Goniothalamus tortilipetalus</i> resulted in the isolation and identification of two new alkaloids, goniotortiline (<b>1</b>) and goniotortilactam (<b>2</b>), three new styryl lactone derivatives, goniotortilactone (<b>3</b>) and goniotortilols A (<b>4</b>) and B (<b>5</b>), and 25 known compounds. Their structures were elucidated by spectroscopic methods and HRESITOFMS data. Compounds <b>5</b>, <b>13</b>, <b>15</b>, <b>16</b>, <b>22</b>, and <b>30</b> inhibited nitric oxide (NO) production with IC<sub>50</sub> values ranging from 8.7 ± 0.1 to 17 ± 1 μM, revealing stronger effects than the standard drug, dexamethasone (IC<sub>50</sub> 16.9 ± 2.2 μM), and compound <b>30</b> possessed the most potent NO production inhibition. Compounds <b>12</b> and <b>29</b> demonstrated notable efficacy in enhancing glucose consumption with IC<sub>50</sub> values of 77 ± 4 and 66 ± 4 μM, respectively, while their glucose uptakes were 1.7- and 2-fold, respectively.
Authors
- Raymond J. Andersen (ORCID: https://orcid.org/0000-0002-7607-8213)
- Phunrawie Promnart (ORCID: https://orcid.org/0009-0005-7741-5567)
- Surat Laphookhieo (ORCID: https://orcid.org/0000-0002-4757-2781)
- Tharakorn Maneerat
- Sorraya Champakam (ORCID: https://orcid.org/0000-0001-5161-8458)
- Sarot Cheenpracha (ORCID: https://orcid.org/0000-0002-4333-1059)
- Somkiat Nokbin (ORCID: https://orcid.org/0000-0001-8621-5894)
- Zi Han Loh (ORCID: https://orcid.org/0000-0002-2437-6526)
- Natcha Injan
- Brian O. Patrick (ORCID: https://orcid.org/0000-0002-2921-8439)
- Siau Hui Mah (ORCID: https://orcid.org/0000-0003-0370-4866)
- Panom Winyayong
Institutions
- University of British Columbia (CA)
- Kasetsart University (TH)
- Mae Fah Luang University (TH)
- University of Phayao (TH)
- Mae Fah Luang University Hospital (TH)
- EarthTech International (United States) (US)
- Taylor's University (MY)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c00933
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mae Fah Luang University
- National Research Council of Thailand
- Ministry of Higher Education, Science, Research and Innovation, Thailand